The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression

Ning Qing Liu; Menno ter Huurne; Luan N. Nguyen; Tianran Peng; Shuang-Yin Wang; James B. Studd; Onkar Joshi; Halit Ongen; Jesper B Bramsen; Jian Yan; Claus L. Andersen; Jussi Taipale; Emmanouil T. Dermitzakis; Richard S. Houlston; Nina C. Hubner; Hendrik G. Stunnenberg

doi:10.1038/ncomms14418

Nature Communications (Feb 2017)

The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression

Ning Qing Liu,
Menno ter Huurne,
Luan N. Nguyen,
Tianran Peng,
Shuang-Yin Wang,
James B. Studd,
Onkar Joshi,
Halit Ongen,
Jesper B Bramsen,
Jian Yan,
Claus L. Andersen,
Jussi Taipale,
Emmanouil T. Dermitzakis,
Richard S. Houlston,
Nina C. Hubner,
Hendrik G. Stunnenberg

Affiliations

Ning Qing Liu: Department of Molecular Biology, Faculty of Science, Radboud University
Menno ter Huurne: Department of Molecular Biology, Faculty of Science, Radboud University
Luan N. Nguyen: Department of Molecular Biology, Faculty of Science, Radboud University
Tianran Peng: Department of Molecular Biology, Faculty of Science, Radboud University
Shuang-Yin Wang: Department of Molecular Biology, Faculty of Science, Radboud University
James B. Studd: Division of Genetics and Epidemiology, Institute of Cancer Research
Onkar Joshi: Department of Molecular Biology, Faculty of Science, Radboud University
Halit Ongen: Department of Genetic Medicine and Development, University of Geneva Medical School
Jesper B Bramsen: Department of Molecular Medicine, Aarhus University Hospital
Jian Yan: Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Claus L. Andersen: Department of Molecular Medicine, Aarhus University Hospital
Jussi Taipale: Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Emmanouil T. Dermitzakis: Department of Genetic Medicine and Development, University of Geneva Medical School
Richard S. Houlston: Division of Genetics and Epidemiology, Institute of Cancer Research
Nina C. Hubner: Department of Molecular Biology, Faculty of Science, Radboud University
Hendrik G. Stunnenberg: Department of Molecular Biology, Faculty of Science, Radboud University

DOI: https://doi.org/10.1038/ncomms14418
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Functional characterisation of non-coding risk variants for colorectal cancer is missing. Here the authors conduct a large-scale proteome-wide analysis of disease associated SNPs to characterize allele-specific transcription factor binding landscape in colorectal cancer and identify one functionally significant SNP.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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