Acta Medica Bulgarica (Apr 2023)

A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina

  • Graiqevci-Uka V.,
  • Behluli E.,
  • Spahiu L.,
  • Liehr T.,
  • Temaj G.

DOI
https://doi.org/10.2478/amb-2023-0009
Journal volume & issue
Vol. 50, no. 1
pp. 59 – 62

Abstract

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Acute lymphoblastic leukemia (ALL) is a malignant disease caused by mutations in B- or T-cell precursors of bone marrow cells. Childhood acute lymphoblastic leukemia (ALL) is a subtype of pediatric cancer with a 1 in 2000 incidence. Here we present a new childhood ALL in a 3-year-old girl. As CD45/19, CD10/19, CD3, CD8, CD10, and CD19 were positive in immunohistochemically analyses of blast cells, a B-ALL was diagnosed with a causative ETV6-RUNX1 gene fusion. The patient was treated based on standard protocols BMF-ALL 2009. Interestingly, an aunt and a grandfather of the patient had experienced malignancies as well, which may be carefully interpreted as a hint on a familial cancer syndrome.

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