Nature Communications (Jun 2022)

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants

  • Scotland E. Farley,
  • Jennifer E. Kyle,
  • Hans C. Leier,
  • Lisa M. Bramer,
  • Jules B. Weinstein,
  • Timothy A. Bates,
  • Joon-Yong Lee,
  • Thomas O. Metz,
  • Carsten Schultz,
  • Fikadu G. Tafesse

DOI
https://doi.org/10.1038/s41467-022-31097-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Here, Farley et al. perform untargeted lipidomics to assess how SARS-CoV-2 rewires host lipid metabolism. SARS-CoV-2 viral proteins specifically induce lipid droplet formation and dramatically change lipid metabolism to support infection; interfering with lipid metabolism using small molecule inhibitors decreases virus production.