Nanotechnology Reviews (Feb 2021)

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

  • Gu Xinyi,
  • Chen Xiaoli,
  • Tang Xiaoxuan,
  • Zhou Zhihao,
  • Huang Tingting,
  • Yang Yumin,
  • Ling Jue

Journal volume & issue
Vol. 10, no. 1
pp. 10 – 19


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Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The hydrogels exhibit excellent mechanical properties with high strength. Good biocompatibility also allows the hydrogels to support cell survival. Significantly, the hydrogel with aligned microgrooved structures enables the aligned growth of Schwann cells. Moreover, the hydrogel holds a strong capacity for promoting axon growth and guiding neurite sprouting. Thus, this micropatterned SF hydrogel would have great potential for peripheral nerve regeneration.