Accessibility of the histone H3 tail in the nucleosome for binding of paired readers

Jovylyn Gatchalian; Xiaodong Wang; Jinzen Ikebe; Khan L. Cox; Adam H. Tencer; Yi Zhang; Nathaniel L. Burge; Luo Di; Matthew D. Gibson; Catherine A. Musselman; Michael G. Poirier; Hidetoshi Kono; Jeffrey J. Hayes; Tatiana G. Kutateladze

doi:10.1038/s41467-017-01598-x

Nature Communications (Nov 2017)

Accessibility of the histone H3 tail in the nucleosome for binding of paired readers

Jovylyn Gatchalian,
Xiaodong Wang,
Jinzen Ikebe,
Khan L. Cox,
Adam H. Tencer,
Yi Zhang,
Nathaniel L. Burge,
Luo Di,
Matthew D. Gibson,
Catherine A. Musselman,
Michael G. Poirier,
Hidetoshi Kono,
Jeffrey J. Hayes,
Tatiana G. Kutateladze

Affiliations

Jovylyn Gatchalian: Department of Pharmacology, University of Colorado School of Medicine
Xiaodong Wang: Department of Biochemistry and Biophysics, University of Rochester Medical Center
Jinzen Ikebe: Molecular Modeling and Simulation Group, National Institutes for Quantum and Radiological Science and Technology, Kizugawa
Khan L. Cox: Department of Physics, Ohio State University, Columbus
Adam H. Tencer: Department of Pharmacology, University of Colorado School of Medicine
Yi Zhang: Department of Pharmacology, University of Colorado School of Medicine
Nathaniel L. Burge: Department of Physics, Ohio State University, Columbus
Luo Di: Molecular Modeling and Simulation Group, National Institutes for Quantum and Radiological Science and Technology, Kizugawa
Matthew D. Gibson: Department of Physics, Ohio State University, Columbus
Catherine A. Musselman: Department of Biochemistry, University of Iowa College of Medicine
Michael G. Poirier: Department of Physics, Ohio State University, Columbus
Hidetoshi Kono: Molecular Modeling and Simulation Group, National Institutes for Quantum and Radiological Science and Technology, Kizugawa
Jeffrey J. Hayes: Department of Biochemistry and Biophysics, University of Rochester Medical Center
Tatiana G. Kutateladze: Department of Pharmacology, University of Colorado School of Medicine

DOI: https://doi.org/10.1038/s41467-017-01598-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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The chromatin remodeller CHD4 contains two PHD finger reader domains that have been shown to bivalently recognize H3 histone tails. Here, the authors describe a mechanism by which the PHD fingers bind to the intact nucleosome core particle, revealing both cooperative and individual interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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