Rifampicin Resistance in Tuberculosis Outbreak, London, England

Abstract

Mycobacterium tuberculosis isolates cultured from 6 patients associated with an isoniazid-resistant M. tuberculosis outbreak acquired rifampicin resistance. The rpoB gene sequence showed that resistance was associated with rare mutations in each isolate. Three isolates had a mutation outside the rifampicin resistance–determining region.

Keywords

• Keywords: Multi-drug resistant Mycobacterium tuberculosis
• sequencing
• rare mutations
• England
• United Kingdom