Multiple Foci of Basal Cell Carcinoma Arising in Rhinophyma: A Case Report and Literature Review
Mario Faenza,
Marcello Molle,
Andrea Ronchi,
Francesca Pagliuca,
Tommaso Pelella,
Maria Maddalena Nicoletti,
Erminia Crisci,
Gorizio Pieretti,
Giuseppe Andrea Ferraro
Affiliations
Mario Faenza
Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli,” Naples, Italy
Marcello Molle
Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli,” Naples, Italy; Corresponding author: Marcello Molle, Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli,” Naples, Italy; P.zza L. Miraglia, 2-Naples, Italy
Andrea Ronchi
Pathology Unit, Mental and Physical Health and Preventive Medicine Department, University of Campania “Luigi Vanvitelli,” Naples, Italy
Francesca Pagliuca
Pathology Unit, Mental and Physical Health and Preventive Medicine Department, University of Campania “Luigi Vanvitelli,” Naples, Italy
Tommaso Pelella
Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli,” Naples, Italy
Maria Maddalena Nicoletti
Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli,” Naples, Italy
Erminia Crisci
Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli,” Naples, Italy
Gorizio Pieretti
Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli,” Naples, Italy
Giuseppe Andrea Ferraro
Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli,” Naples, Italy
Background: Rhinophyma is a benign condition caused by the excessive growth of sebaceous glands in the nasal tissue, presenting with symptoms such as nasal hypertrophy, erythema, and papules. Cases of basal cell carcinoma in rhinophyma have been reported in literature, but its etiological role remains unclear. It is uncertain whether rhinophyma is predisposed to neoplasm development or if their coexistence is coincidental. Material and Method: We conducted a literature survey to identify such cases reported over the years. Results: We identified 22 studies reporting a total of 47 cases in the literature, all involving male patients. The most common pattern of occurrence was the rapid growth of a nodular formation within the context of rhinophyma. Discussions and Conclusion: The elucidation of the association between basal cell carcinoma and rhinophyma remains challenging. The presence of multiple foci supports the theory that rhinophyma may play a role in their development, but larger studies are needed to establish a causal relationship.
