BMJ Open (Dec 2021)
Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland
- Thomas Fehr,
- Pierre-Yves Bochud,
- Oriol Manuel,
- Roger Lehmann,
- Christoph Berger,
- Klara Posfay-Barbe,
- Frank Ruschitzka,
- Manuel Pascual,
- Michael Koller,
- Heiner Bucher,
- Thomas Schachtner,
- Annalisa Berzigotti,
- Christoph Hess,
- Sylvie Ferrari-Lacraz,
- Dominik Heim,
- Sabina de Geest,
- Jürg Steiger,
- Simona Rossi,
- Christian Garzoni,
- Thierry Carrel,
- Sabina De Geest,
- Christian van Delden,
- Beat Mullhaupt,
- Nicolas Goossens,
- Guido Beldi,
- Uyen Huynh-Do,
- Karine Hadaya,
- Sophie De Seigneux,
- Susanne Stampf,
- Nicolas J Mueller,
- Vanessa Banz,
- Isabelle Binet,
- Alexander Leichtle,
- Stefan Schaub,
- Patrizia Amico,
- Andres Axel,
- John-David Aubert,
- Beckmann Sonja,
- Ekaterine Berishvili,
- Sanda Branca,
- Emmanuelle Catana,
- Olivier De Rougemont,
- Michael Dickenmann,
- Joëlle Lynn Dreifuss,
- Michel Duchosal,
- Nicola Franscini,
- Paola Gasche Soccal,
- Christophe Gaudet,
- Déla Golshayan,
- Jörg Halter,
- Sven Hillinger,
- Hans Hirsch,
- Patricia Hirt,
- Günther Hofbauer,
- Franz Immer,
- Mirjam Laager,
- Bettina Laesser,
- Christian Lovis,
- Hans-Peter Marti,
- Pierre Yves Martin,
- Michele Martinelli,
- Valérie McLin,
- Katell Mellac,
- Aurélia Merçay,
- Karin Mettler,
- Nicolas Mueller,
- Antonia Müller,
- Ulrike Müller-Arndt,
- Mirjam Nägeli,
- Graziano Oldani,
- Juliane Rick,
- Anne Rosselet,
- Silvia Rothlin,
- Urs Schanz,
- Aurelia Schnyder,
- Macé Schuurmans,
- Thierry Sengstag,
- Federico Simonetta,
- Guido Stirniman,
- Ueli Stürzinger,
- Christian Van Delden,
- Jean-Pierre Venetz,
- Jean Villard,
- Julien Vionnet,
- Madeleine Wick,
- Markus Wilhlem,
- Patrick Yerly
Affiliations
- Thomas Fehr
- Department of Internal Medicine, Kantonsspital Graubünden, Chur, Graubünden, Switzerland
- Pierre-Yves Bochud
- Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Oriol Manuel
- Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Roger Lehmann
- Endokrinologie, Diabetologie und Klinische Ernährung, UniversitätsSpital Zürich, Zurich, Switzerland
- Christoph Berger
- 1University Children’s Hospital Zurich, Department of Infectious Diseases and Hospital Epidemiology, 8032 Zurich
- Klara Posfay-Barbe
- Frank Ruschitzka
- Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland
- Manuel Pascual
- Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Michael Koller
- Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
- Heiner Bucher
- Thomas Schachtner
- Annalisa Berzigotti
- Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
- Christoph Hess
- Sylvie Ferrari-Lacraz
- Dominik Heim
- 1 Division of Hematology, University Hospital, Basel, Switzerland
- Sabina de Geest
- Department of Public Health, Institute of Nursing Science, University of Basel, Basel, Switzerland
- Jürg Steiger
- Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
- Simona Rossi
- Christian Garzoni
- Thierry Carrel
- Sabina De Geest
- Christian van Delden
- Transplant Infectious Diseases Unit, University Hospitals Geneva and Faculty of Medicine, Geneva, Switzerland
- Beat Mullhaupt
- Nicolas Goossens
- Department of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva, Switzerland
- Guido Beldi
- Uyen Huynh-Do
- 8 Division of Nephrology and Hypertension, University Hospital Bern, Bern, Switzerland
- Karine Hadaya
- Sophie De Seigneux
- Service of Nephrology, Department of Medicine, University Hospital of Geneva, Geneva, Switzerland
- Susanne Stampf
- Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
- Nicolas J Mueller
- Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- Vanessa Banz
- Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland
- Isabelle Binet
- Nephrology and Transplantation Medicine, Kantonsspital St Gallen, Sankt Gallen, Switzerland
- Alexander Leichtle
- Center for Laboratory Medicine, University Institute of Clinical Chemistry, Inselspital University Hospital Bern, Bern, Switzerland
- Stefan Schaub
- Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
- Patrizia Amico
- Andres Axel
- John-David Aubert
- Beckmann Sonja
- Ekaterine Berishvili
- Sanda Branca
- Emmanuelle Catana
- Olivier De Rougemont
- Michael Dickenmann
- Joëlle Lynn Dreifuss
- Michel Duchosal
- Nicola Franscini
- Paola Gasche Soccal
- Christophe Gaudet
- Déla Golshayan
- Jörg Halter
- Sven Hillinger
- Hans Hirsch
- Patricia Hirt
- Günther Hofbauer
- Franz Immer
- Mirjam Laager
- Bettina Laesser
- Christian Lovis
- Hans-Peter Marti
- Pierre Yves Martin
- Michele Martinelli
- Valérie McLin
- Katell Mellac
- Aurélia Merçay
- Karin Mettler
- Nicolas Mueller
- Antonia Müller
- Ulrike Müller-Arndt
- Mirjam Nägeli
- Graziano Oldani
- Juliane Rick
- Anne Rosselet
- Silvia Rothlin
- Urs Schanz
- Aurelia Schnyder
- Macé Schuurmans
- Thierry Sengstag
- Federico Simonetta
- Guido Stirniman
- Ueli Stürzinger
- Christian Van Delden
- Jean-Pierre Venetz
- Jean Villard
- University Hospitals of Geneva, Geneva, Switzerland
- Julien Vionnet
- Service of Gastroenterology and Hepatology, Lausanne University Hospital, Lausanne, Switzerland
- Madeleine Wick
- Markus Wilhlem
- Patrick Yerly
- DOI
- https://doi.org/10.1136/bmjopen-2021-051176
- Journal volume & issue
-
Vol. 11,
no. 12
Abstract
Purpose The Swiss Transplant Cohort Study (STCS) is a prospective multicentre cohort study which started to actively enrol study participants in May 2008. It takes advantage of combining data from all transplant programmes in one unique system to perform comprehensive nationwide reporting and to promote translational and clinical post-transplant outcome research in the framework of Swiss transplantation medicine.Participants Over 5500 solid organ transplant recipients have been enrolled in all six Swiss transplant centres by end of 2019, around three-quarter of them for kidney and liver transplants. Ninety-three per cent of all transplanted recipients have consented to study participation, almost all of them (99%) contributed to bio-sampling. The STCS genomic data set includes around 3000 patients.Findings to date Detailed clinical and laboratory data in high granularity as well as patient-reported outcomes from transplant recipients and activities in Switzerland are available in the last decade. Interdisciplinary contributions in diverse fields of transplantation medicine such as infectious diseases, genomics, oncology, immunology and psychosocial science have resulted in approximately 70 scientific papers getting published in peer-review journals so far.Future plans The STCS will deepen its efforts in personalised medicine and digital epidemiology, and will also focus on allocation research and the use of causal inference methods to make complex matters in transplant medicine more understandable and transparent.
