Бюллетень сибирской медицины (Jun 2014)

DEVIATIONS IN MENTAL DEVELOPMENT OF THE OFFSPRING OF RATS WITH EXPERIMENTAL PREECLAMPSIA AND THEIR CORRECTION BY NEW DERIVATIVE OF GAMMA-AMINOBUTYRIC ACID

  • I. N. Tyurenkov,
  • V. N. Perfilova,
  • L. I. Mikhailova,
  • G. A. Zhakupova,
  • S. A. Lebedeva

DOI
https://doi.org/10.20538/1682-0363-2014-3-56-62
Journal volume & issue
Vol. 13, no. 3
pp. 56 – 62

Abstract

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The aim of investigation was to study the effect of a gamma-aminobutyric acid´s derivative – a compound RGPU-242 – on the mental development of the rat´s offspring with experimental preeclampsia. Famels’s preeclampsia was modeled by replacing the drinking water of 1.8% sodium chloride solution from 7th to the 21th day of gestation. Locomotion, indicative and emotional activity and cognitive functions in progeny were recorded on “Open field”, “One-way step-down inhibitory (“passive”) avoidance”, “Elevated plus maze” and “Test of extrapolative escape” tests in different periods of postnatal development. Found that the compound RGPU-242 has gravidoprotective effect, improves formation and development of mental functions in the offspring.

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