Frontiers in Oncology (Dec 2022)
Diagnostic and surgical management of primary central nervous system angioleiomyoma: A case report and literature review
- Emanuele Rubiu,
- Emanuele Rubiu,
- Emanuele La Corte,
- Emanuele La Corte,
- Giulio Bonomo,
- Giulio Bonomo,
- Francesco Restelli,
- Francesco Restelli,
- Jacopo Falco,
- Jacopo Falco,
- Elio Mazzapicchi,
- Elio Mazzapicchi,
- Morgan Broggi,
- Marco Paolo Schiariti,
- Bianca Pollo,
- Valentina Pinzi,
- Maria Grazia Bruzzone,
- Francesco Di Meco,
- Francesco Di Meco,
- Francesco Di Meco,
- Francesco Acerbi,
- Francesco Acerbi,
- Paolo Ferroli
Affiliations
- Emanuele Rubiu
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Emanuele Rubiu
- University of Milan, Milan, Italy
- Emanuele La Corte
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Emanuele La Corte
- Alma Mater Studiorum University of Bologna, Bologna, Italy
- Giulio Bonomo
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Giulio Bonomo
- University of Milan, Milan, Italy
- Francesco Restelli
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Francesco Restelli
- University of Milan, Milan, Italy
- Jacopo Falco
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Jacopo Falco
- University of Milan, Milan, Italy
- Elio Mazzapicchi
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Elio Mazzapicchi
- University of Milan, Milan, Italy
- Morgan Broggi
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Marco Paolo Schiariti
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Bianca Pollo
- Neuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Valentina Pinzi
- Radiotherapy Unit, Department of Radiosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Maria Grazia Bruzzone
- Neuroradiology Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Francesco Di Meco
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Francesco Di Meco
- Department of Oncology and Hematology-Oncology, University of Milan, Milan, Italy
- Francesco Di Meco
- Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, MD, United States
- Francesco Acerbi
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- Francesco Acerbi
- University of Milan, Milan, Italy
- Paolo Ferroli
- Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
- DOI
- https://doi.org/10.3389/fonc.2022.1072270
- Journal volume & issue
-
Vol. 12
Abstract
Angioleiomyoma (ALM) is a benign smooth muscle neoplasm that mainly occurs in lower extremities subcutaneous tissue and generally affects middle-aged adults. This tumor histotype may rarely localize intracranially, although only a few cases have been described in the literature. We report a case of intracranial ALM, whose differential diagnosis has been particularly challenging, and firstly provide a comprehensive radiological and intra-operative evaluation of a such rare entity. This represents also the first report of the use of intraoperative confocal microscopy in ALM and the first documented short-term recurrence. At this regard, a scoping literature review has been conducted with the aim of presenting the major clinical and diagnostic features along with the proposed therapeutic strategies.
Keywords
