Protocol for Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS): rationale, design and database building
Jing Li,
Rui Li,
Jing Sun,
Ning Wu,
Wenjuan Liu,
Yuntao Wu,
Shouling Wu,
Xinyu Zhao,
Qian Chen,
Aijun Xing,
Pengfei Zhao,
Ying Hui,
Xiaoshuai Li,
Mingze Xu,
Huijing Shi,
Shun Zhang,
Xiaoliang Liang,
Yongxin Wang,
Han Lv,
Zhenchang Wang
Affiliations
Jing Li
1 Xijing Hypertrophic Cardiomyopathy Center, Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xian, Shaanxi, China
Rui Li
1 Department of Geriatric Neurology, Shaanxi Provincial People`s Hospital, Xi`an, Shaanxi, China
Jing Sun
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), VIP-II Gastrointestinal Cancer Division of the Department of Medicine, Peking University Cancer Hospital, Beijing, China
Ning Wu
Department of Diagnostic Radiology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Wenjuan Liu
1 Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China
Yuntao Wu
Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China
Shouling Wu
3 Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China
Xinyu Zhao
Department of Clinical Epidemiology and EBM, Beijing Friendship Hospital, Capital Medical University; National Clinical Research Center for Digestive Diseases, Beijing, China
Qian Chen
Ministry of Education-Shanghai Key Laboratory of Children`s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Aijun Xing
Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China
Pengfei Zhao
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Ying Hui
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Xiaoshuai Li
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Mingze Xu
Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
Huijing Shi
Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, Hebei, China
Shun Zhang
Department of Psychiatry, Kailuan Mental Health Center, Tangshan, Hebei, China
Xiaoliang Liang
Department of Psychiatry, Kailuan Mental Health Center, Tangshan, Hebei, China
Yongxin Wang
Department of MR, Kailuan General Hospital, Tangshan, Hebei, China
Han Lv
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Zhenchang Wang
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Introduction Multi-modality medical imaging study, especially brain MRI, greatly facilitates the research on subclinical brain disease. However, there is still a lack of such studies with a wider age span of participants. The Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS) was designed to address this issue with a large sample size population.Methods and analysis We aim to enrol at least 1000 subjects in META-KLS. All the participants without contraindications will perform multi-modality medical imaging, including brain MRI, retinal fundus photograph, fundus optical coherence tomography (OCT) and ultrasonography of the internal carotid artery (ICA) every 2–4 years. The acquired medical imaging will be further processed with a standardised and validated workflow. The clinical data at baseline and follow-up will be collected from the KaiLuan Study. The associations between multiple risk factors and subclinical brain disease are able to be fully investigated. Researches based on META-KLS will provide a series of state-of-the-art evidence for the prevention of neurological diseases and common chronic diseases.Ethics and dissemination The Kailuan Study and META-KLS have been approved by the Medical Ethics Committee of Kailuan General Hospital (IRB number: 2008 No. 1 and 2021002, respectively). Written informed consent will be acquired from each participant. Results are expected to be published in professional peer-reviewed journals beginning in 2023.Trial registration number NCT05453877.
