Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis

Dalia E. Gaddis; Lindsey E. Padgett; Runpei Wu; Chantel McSkimming; Veronica Romines; Angela M. Taylor; Coleen A. McNamara; Mitchell Kronenberg; Shane Crotty; Michael J. Thomas; Mary G. Sorci-Thomas; Catherine C. Hedrick

doi:10.1038/s41467-018-03493-5

Nature Communications (Mar 2018)

Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis

Dalia E. Gaddis,
Lindsey E. Padgett,
Runpei Wu,
Chantel McSkimming,
Veronica Romines,
Angela M. Taylor,
Coleen A. McNamara,
Mitchell Kronenberg,
Shane Crotty,
Michael J. Thomas,
Mary G. Sorci-Thomas,
Catherine C. Hedrick

Affiliations

Dalia E. Gaddis: Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology
Lindsey E. Padgett: Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology
Runpei Wu: Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology
Chantel McSkimming: Cardiovascular Research Center and Division of Cardiology, University of Virginia
Veronica Romines: Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology
Angela M. Taylor: Cardiovascular Research Center and Division of Cardiology, University of Virginia
Coleen A. McNamara: Cardiovascular Research Center and Division of Cardiology, University of Virginia
Mitchell Kronenberg: Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
Shane Crotty: Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
Michael J. Thomas: Department of Pharmacology and Toxicology, Medical College of Wisconsin
Mary G. Sorci-Thomas: Department of Pharmacology and Toxicology, Medical College of Wisconsin
Catherine C. Hedrick: Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology

DOI: https://doi.org/10.1038/s41467-018-03493-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here Gaddis et al. show that Apolipoprotein AI prevents the conversion of Treg cells into pro-atherogenic T follicular helper cells, and thus regulates the immune response during atherogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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