Nature Communications (Nov 2021)
Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
- Joschka Heil,
- Victor Olsavszky,
- Katrin Busch,
- Kay Klapproth,
- Carolina de la Torre,
- Carsten Sticht,
- Kajetan Sandorski,
- Johannes Hoffmann,
- Hiltrud Schönhaber,
- Johanna Zierow,
- Manuel Winkler,
- Christian David Schmid,
- Theresa Staniczek,
- Deborah E. Daniels,
- Jan Frayne,
- Georgia Metzgeroth,
- Daniel Nowak,
- Sven Schneider,
- Michael Neumaier,
- Vanessa Weyer,
- Christoph Groden,
- Hermann-Josef Gröne,
- Karsten Richter,
- Carolin Mogler,
- Makoto Mark Taketo,
- Kai Schledzewski,
- Cyrill Géraud,
- Sergij Goerdt,
- Philipp-Sebastian Koch
Affiliations
- Joschka Heil
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Victor Olsavszky
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Katrin Busch
- Division of Cellular Immunology, German Cancer Research Center (DKFZ)
- Kay Klapproth
- Division of Cellular Immunology, German Cancer Research Center (DKFZ)
- Carolina de la Torre
- Core Facility Platform Mannheim (CFPM), NGS Core Facility, Medical Faculty Mannheim, Heidelberg University
- Carsten Sticht
- Core Facility Platform Mannheim (CFPM), NGS Core Facility, Medical Faculty Mannheim, Heidelberg University
- Kajetan Sandorski
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Johannes Hoffmann
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Hiltrud Schönhaber
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Johanna Zierow
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Manuel Winkler
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Christian David Schmid
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Theresa Staniczek
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Deborah E. Daniels
- School of Biochemistry, University of Bristol
- Jan Frayne
- School of Biochemistry, University of Bristol
- Georgia Metzgeroth
- Department for Hematology and Oncology, University Medical Center and Medical Faculty Mannheim, Heidelberg University
- Daniel Nowak
- Department for Hematology and Oncology, University Medical Center and Medical Faculty Mannheim, Heidelberg University
- Sven Schneider
- Institute for Clinical Chemistry, University Medical Center and Medical Faculty Mannheim, Heidelberg University
- Michael Neumaier
- Institute for Clinical Chemistry, University Medical Center and Medical Faculty Mannheim, Heidelberg University
- Vanessa Weyer
- Department of Neuroradiology, University Medical Center and Medical Faculty Mannheim, Heidelberg University
- Christoph Groden
- Department of Neuroradiology, University Medical Center and Medical Faculty Mannheim, Heidelberg University
- Hermann-Josef Gröne
- Institute of Pharmacology, Philipps-University
- Karsten Richter
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Carolin Mogler
- Institute of Pathology, Technical University Munich
- Makoto Mark Taketo
- Division of Experimental Therapeutics, Graduate School of Medicine, Kyoto University
- Kai Schledzewski
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Cyrill Géraud
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Sergij Goerdt
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- Philipp-Sebastian Koch
- Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology
- DOI
- https://doi.org/10.1038/s41467-021-27161-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre driven overactivation of b-catenin leads to erythroid differentiation defects and anaemia.
