Communications Biology (Feb 2021)

IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice

  • Carolin K. Koss,
  • Christian T. Wohnhaas,
  • Jonathan R. Baker,
  • Cornelia Tilp,
  • Michèl Przibilla,
  • Carmen Lerner,
  • Silvia Frey,
  • Martina Keck,
  • Cara M. M. Williams,
  • Daniel Peter,
  • Meera Ramanujam,
  • Jay Fine,
  • Florian Gantner,
  • Matthew Thomas,
  • Peter J. Barnes,
  • Louise E. Donnelly,
  • Karim C. El Kasmi

DOI
https://doi.org/10.1038/s42003-021-01703-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Carolin Koss et al. show that IL-36 produced from neutrophils is a key amplifier of lung inflammation in mice by activating neutrophils, macrophages and fibroblasts in cooperation with GM-CSF and the viral mimic poly(I:C). This study suggests that targeting IL-36 may improve the treatment of neutrophilic lung diseases.