Analysis of the genomic homologous recombination in <it>Theilovirus </it>based on complete genomes

Virology Journal. 2011;8(1):439 DOI 10.1186/1743-422X-8-439


Journal Homepage

Journal Title: Virology Journal

ISSN: 1743-422X (Online)

Publisher: BMC

LCC Subject Category: Medicine: Internal medicine: Infectious and parasitic diseases

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML



Yi Maoli

Zhang Xiaodan

Sun Guangming

Shao Shihe

Zhang Wen


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 11 weeks


Abstract | Full Text

<p>Abstract</p> <p>At present, <it>Theilovirus </it>is considered to comprise four distinct serotypes, including Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, Thera virus, and Saffold virus. So far, there is no systematical study that investigated the genomic recombination of <it>Theilovirus</it>. The present study performed the phylogenetic and recombination analysis of <it>Theilovirus </it>over the complete genomes. Seven potentially significant recombination events were identified. However, according to the strains information and references related to the recombinants and their parental strains, four of the recombination events might happen non-naturally. These results will provide valuable hints for future research on evolution and antigenic variability of Theilovirus.</p>