HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism

Sampath Narayanan; Sofie Eliasson Angelstig; Cheng Xu; Jacob Grünler; Allan Zhao; Wan Zhu; Ning Xu Landén; Mona Ståhle; Jingping Zhang; Mircea Ivan; Raluca Georgiana Maltesen; Ileana Ruxandra Botusan; Neda Rajamand Ekberg; Xiaowei Zheng; Sergiu-Bogdan Catrina

doi:10.1038/s42003-020-01495-y

Communications Biology (Dec 2020)

HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism

Sampath Narayanan,
Sofie Eliasson Angelstig,
Cheng Xu,
Jacob Grünler,
Allan Zhao,
Wan Zhu,
Ning Xu Landén,
Mona Ståhle,
Jingping Zhang,
Mircea Ivan,
Raluca Georgiana Maltesen,
Ileana Ruxandra Botusan,
Neda Rajamand Ekberg,
Xiaowei Zheng,
Sergiu-Bogdan Catrina

Affiliations

Sampath Narayanan: Department of Molecular Medicine and Surgery, Karolinska Institutet
Sofie Eliasson Angelstig: Department of Molecular Medicine and Surgery, Karolinska Institutet
Cheng Xu: Department of Molecular Medicine and Surgery, Karolinska Institutet
Jacob Grünler: Department of Molecular Medicine and Surgery, Karolinska Institutet
Allan Zhao: Department of Molecular Medicine and Surgery, Karolinska Institutet
Wan Zhu: Department of Nosocomial Infection Control, China Medical University
Ning Xu Landén: Dermatology and Venereology division, Department of Medicine Solna, Center for Molecular Medicine and Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet
Mona Ståhle: Dermatology and Venereology division, Department of Medicine Solna, Center for Molecular Medicine and Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet
Jingping Zhang: Department of Infectious Disease, China Medical University
Mircea Ivan: Departments of Medicine, Microbiology and Immunology, Indiana University
Raluca Georgiana Maltesen: Department of Anesthesia and Intensive Care Medicine, Aalborg University Hospital
Ileana Ruxandra Botusan: Department of Molecular Medicine and Surgery, Karolinska Institutet
Neda Rajamand Ekberg: Department of Molecular Medicine and Surgery, Karolinska Institutet
Xiaowei Zheng: Department of Molecular Medicine and Surgery, Karolinska Institutet
Sergiu-Bogdan Catrina: Department of Molecular Medicine and Surgery, Karolinska Institutet

DOI: https://doi.org/10.1038/s42003-020-01495-y
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 11

Abstract

Read online

Narayanan et al. show that local administration of miR-210 accelerates wound healing specifically in diabetic mice. They find that miR-210 restores the metabolic balance in diabetic wounds by activating glycolysis and cellular migration. This study presents miR-210 as a potential therapeutic option to treat diabetic wound healing.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal