Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer

Abstract

Yanrong Cai,1 Lieping Guo,2 Hongxing Shen,2 Xiaofei An,2 Hong Jiang,3 Fang Ji,2 Yunfei Niu21The College of Basic Science of Medicine, Hunan University of Traditional Chinese Medicine, Changsha, 2Department of Orthopaedics, Changhai Hospital, Second Military Medical University, 3School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People’s Republic of ChinaAbstract: Biocomposite scaffolds of lithium (Li)-containing mesoporous bioglass and monomethoxy poly(ethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine) (mPEG-PLGA-b-PLL) copolymer were fabricated in this study. The results showed that the water absorption and degradability of Li-containing mesoporous bioglass/mPEG-PLGA-b-PLL composite (l-MBPC) scaffolds were obviously higher than Li-containing bioglass/mPEG-PLGA-b-PLL composite (l-BPC) scaffolds. Moreover, the apatite-formation ability of l-MBPC scaffolds was markedly enhanced as compared with l-BPC scaffolds, indicating that l-MBPC scaffolds containing mesoporous bioglass exhibited good bioactivity. The cell experimental results showed that cell attachment, proliferation, and alkaline phosphatase activity of MC3T3-E1 cells on l-MBPC scaffolds were remarkably improved as compared to l-BPC scaffolds. In animal experiments, the histological elevation results revealed that l-MBPC scaffolds significantly promoted new bone formation, indicating good osteogenesis. l-MBPC scaffolds with improved properties would be an excellent candidate for bone tissue repair.Keywords: MBG, copolymer, degradability, bioactivity, osteogenesis, cell proliferation, bone repair