Nature Communications (Jul 2019)

Adult stem cell deficits drive Slc29a3 disorders in mice

  • Sreenath Nair,
  • Anne M. Strohecker,
  • Avinash K. Persaud,
  • Bhawana Bissa,
  • Shanmugam Muruganandan,
  • Craig McElroy,
  • Rakesh Pathak,
  • Michelle Williams,
  • Radhika Raj,
  • Amal Kaddoumi,
  • Alex Sparreboom,
  • Aaron M. Beedle,
  • Rajgopal Govindarajan

DOI
https://doi.org/10.1038/s41467-019-10925-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 20

Abstract

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Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misregulation of the AMPK-mTOR-ULK axis.