Nature Communications (Aug 2021)
Vertically transferred maternal immune cells promote neonatal immunity against early life infections
- Ina Annelies Stelzer,
- Christopher Urbschat,
- Steven Schepanski,
- Kristin Thiele,
- Ioanna Triviai,
- Agnes Wieczorek,
- Malik Alawi,
- Denise Ohnezeit,
- Julian Kottlau,
- Jiabin Huang,
- Nicole Fischer,
- Hans-Willi Mittrücker,
- Maria Emilia Solano,
- Boris Fehse,
- Anke Diemert,
- Felix R. Stahl,
- Petra Clara Arck
Affiliations
- Ina Annelies Stelzer
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
- Christopher Urbschat
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
- Steven Schepanski
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
- Kristin Thiele
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
- Ioanna Triviai
- Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf
- Agnes Wieczorek
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
- Malik Alawi
- Bioinformatics Core, University Medical Center Hamburg-Eppendorf
- Denise Ohnezeit
- Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf
- Julian Kottlau
- Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Jiabin Huang
- Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf
- Nicole Fischer
- Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf
- Hans-Willi Mittrücker
- Department of Immunology, University Medical Center Hamburg-Eppendorf
- Maria Emilia Solano
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
- Boris Fehse
- Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf
- Anke Diemert
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
- Felix R. Stahl
- Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf
- Petra Clara Arck
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg
- DOI
- https://doi.org/10.1038/s41467-021-24719-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Maternal immune cells seed into the foetus during mammalian pregnancy, yet the functional role of these cells is unclear. Here the authors show that maternal immune cells in foetal bone marrow stimulate immune development, subsequently reducing the risk or severity of infections in newborns.
