Nature Communications (Jul 2022)
A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours
- Akram A. Hamed,
- Daniel J. Kunz,
- Ibrahim El-Hamamy,
- Quang M. Trinh,
- Omar D. Subedar,
- Laura M. Richards,
- Warren Foltz,
- Garrett Bullivant,
- Matthaeus Ware,
- Maria C. Vladoiu,
- Jiao Zhang,
- Antony M. Raj,
- Trevor J. Pugh,
- Michael D. Taylor,
- Sarah A. Teichmann,
- Lincoln D. Stein,
- Benjamin D. Simons,
- Peter B. Dirks
Affiliations
- Akram A. Hamed
- Department of Molecular Genetics, University of Toronto
- Daniel J. Kunz
- The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Ibrahim El-Hamamy
- Department of Molecular Genetics, University of Toronto
- Quang M. Trinh
- Ontario Institute for Cancer Research
- Omar D. Subedar
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Laura M. Richards
- Department of Medical Biophysics, University of Toronto
- Warren Foltz
- STTARR Innovation Centre, Department of Radiation Oncology, University Health Network
- Garrett Bullivant
- Department of Molecular Genetics, University of Toronto
- Matthaeus Ware
- Department of Molecular Genetics, University of Toronto
- Maria C. Vladoiu
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Jiao Zhang
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Antony M. Raj
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Trevor J. Pugh
- Ontario Institute for Cancer Research
- Michael D. Taylor
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Sarah A. Teichmann
- Cavendish Laboratory, Department of Physics, JJ Thomson Avenue
- Lincoln D. Stein
- Department of Molecular Genetics, University of Toronto
- Benjamin D. Simons
- Cavendish Laboratory, Department of Physics, JJ Thomson Avenue
- Peter B. Dirks
- Department of Molecular Genetics, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-022-31408-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The link between neural development and tumourigenesis in adult glioma remains unclear. Here, the authors monitor the developmental stages of Sox2 + /− stem cells from a mouse model using single-cell RNA sequencing and suggest the acquisition of embryonic-like states in the adult glioma development.
