Nature Communications (Aug 2018)
Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
- Min-Sik Lee,
- Hyun-Ji Han,
- Su Yeon Han,
- Il Young Kim,
- Sehyun Chae,
- Choong-Sil Lee,
- Sung Eun Kim,
- Seul Gi Yoon,
- Jun-Won Park,
- Jung-Hoon Kim,
- Soyeon Shin,
- Manhyung Jeong,
- Aram Ko,
- Ho-Young Lee,
- Kyoung-Jin Oh,
- Yun-Hee Lee,
- Kwang-Hee Bae,
- Seung-Hoi Koo,
- Jea-woo Kim,
- Je Kyung Seong,
- Daehee Hwang,
- Jaewhan Song
Affiliations
- Min-Sik Lee
- Harvard Medical School, Boston Children’s Hospital
- Hyun-Ji Han
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Su Yeon Han
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Il Young Kim
- Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science and BK21 Program for Creative Veterinary Science and Research, College of Veterinary Medicine, Seoul National University
- Sehyun Chae
- Center for Plant Aging Research, Institute for Basic Science, and Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST)
- Choong-Sil Lee
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Sung Eun Kim
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Seul Gi Yoon
- Korea Mouse Phenotyping Center (KMPC), Seoul National University
- Jun-Won Park
- Korea Mouse Phenotyping Center (KMPC), Seoul National University
- Jung-Hoon Kim
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Soyeon Shin
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Manhyung Jeong
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Aram Ko
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Ho-Young Lee
- Department of Nuclear Medicine, Seoul National University Bundang Hospital
- Kyoung-Jin Oh
- Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Yun-Hee Lee
- College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University
- Kwang-Hee Bae
- Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Seung-Hoi Koo
- Division of Life Sciences, College of Life Sciences & Biotechnology, Korea University
- Jea-woo Kim
- Department of Biochemistry and Molecular Biology, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine
- Je Kyung Seong
- Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science and BK21 Program for Creative Veterinary Science and Research, College of Veterinary Medicine, Seoul National University
- Daehee Hwang
- Center for Plant Aging Research, Institute for Basic Science, and Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST)
- Jaewhan Song
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- DOI
- https://doi.org/10.1038/s41467-018-05721-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulation.
