Comparative Effectiveness of Omeprazole and Lansoprazole in Gastroesophageal Reflux Disease (GERD): A Review Article

Abstract

This review discusses the use of Omeprazole and Lansoprazole as therapy in patients with Gastroesophageal Reflux Disease (GERD). GERD is a digestive tract disorder caused by repeated reflux of stomach contents into the esophagus. GERD is often characterized by symptoms of a burning and burning chest (heartburn). The most widely used pharmacological therapy to treat GERD is Proton Pump Inhibitor (PPI) drugs, such as Omeprazole and Lansoprazole with a working mechanism that inhibits the proton pump that H+ ions exit from the gastric parietal cells. The method used in writing this article review is an electronic literature study by accessing national and international journal search sites. The results obtained are based on effectiveness, Omeprazole is more effective and faster in reducing and maintaining gastric acid pH. Based on the adverse effects of the drug, Omeprazole has a lower potential risk of causing diarrhea. Omeprazole has the most minimal cost analysis when viewed from the cost aspect and Omeprazole has a faster onset than Lansoprazole.

Keywords

• drug effectiveness
• gastroesophageal reflux disease
• lansoprazole
• omeprazole