Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction

Xia Chen; Peiliang Wang; Hui Qiu; Yonglin Zhu; Xingwu Zhang; Yaxuan Zhang; Fuyu Duan; Shuangyuan Ding; Jianying Guo; Yue Huang; Jie Na

doi:10.1038/s41467-022-30789-4

Nature Communications (Jun 2022)

Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction

Xia Chen,
Peiliang Wang,
Hui Qiu,
Yonglin Zhu,
Xingwu Zhang,
Yaxuan Zhang,
Fuyu Duan,
Shuangyuan Ding,
Jianying Guo,
Yue Huang,
Jie Na

Affiliations

Xia Chen: Tsinghua-Peking Center for Life Sciences
Peiliang Wang: Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Hui Qiu: Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Yonglin Zhu: Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Xingwu Zhang: Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Yaxuan Zhang: Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Fuyu Duan: Guangzhou Women and Children’s Medical Center
Shuangyuan Ding: Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University
Jianying Guo: Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital
Yue Huang: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College
Jie Na: Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University

DOI: https://doi.org/10.1038/s41467-022-30789-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Here they perform an integrative analysis of the epigenetic landscape of human pluripotent stem cell hematopoietic differentiation and show that JUNB is an indispensable transcription factor for hemogenic endothelium development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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