Patient Preference and Adherence (Feb 2022)

The Association Between the Prevalence, Medication Adherence and Control of Hypertension and the Prevalence of Mild Cognitive Impairment in Rural Northern China: A Cross-Sectional Study

  • Ma LY,
  • He F,
  • Liu S,
  • Wang XD,
  • Gao Y,
  • Shi Z,
  • Niu J,
  • Ji Y

Journal volume & issue
Vol. Volume 16
pp. 493 – 502

Abstract

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Ling-Yun Ma,1,* Fangfang He,2,* Shuai Liu,3 Xiao-Dan Wang,3 Yanqin Gao,2 Zhihong Shi,3,4 Jianping Niu,2 Yong Ji1,3,4 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, People’s Republic of China; 3Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Department of Neurology, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, People’s Republic of China; 4China National Clinical Research Center for Neurological Diseases, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianping Niu; Yong Ji, Tel +8618059218208 ; +8613612048681, Email [email protected]; [email protected]; [email protected]: High blood pressure is one of the main modifiable risk factors for dementia. However, it remains unclear whether lowering the blood pressure effectively prevents cognitive impairment. Our objective was to explore the association between the prevalence, medication adherence and control of hypertension and mild cognitive impairment (MCI) among elderly individuals in northern China.Methods: A two-stage clustering sampling method was used, and 9036 participants aged ≥ 65 years were included in the analysis. The Mini-Mental State Examination and activities of daily living were used to assess participants’ cognitive function. Demographic characteristics (gender, age, marital status, education level, occupation), history and duration of hypertension, use of antihypertensive medications (AHMs) and its control effect were obtained.Results: The prevalence of MCI in all participants was 18.1%, and the prevalence of MCI was significantly higher in hypertensive subjects than in normotensive subjects (19.7% vs 16.2%, P

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