Nature Communications (Sep 2018)

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

  • Muhammad Shoaib,
  • David Walter,
  • Peter J. Gillespie,
  • Fanny Izard,
  • Birthe Fahrenkrog,
  • David Lleres,
  • Mads Lerdrup,
  • Jens Vilstrup Johansen,
  • Klaus Hansen,
  • Eric Julien,
  • J. Julian Blow,
  • Claus S. Sørensen

DOI
https://doi.org/10.1038/s41467-018-06066-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Cell cycle and replication need to be tightly regulated to ensure genome stability in mammalian cells. Here the authors provide a link between chromatin structure and DNA replication regulation by showing that chromatin compaction limits replication licensing thereby promoting genome integrity.