Molecular mechanisms for pharmacological effects of drugs based on Cimicifuga racemosa extracts
O.A.Gromova,
I.Yu.Torshin,
N.K.Tetruashvili,
L.E.Fedotova,
N.P.Lapochkina
Affiliations
O.A.Gromova
1Federal Research Centre "Information and Management" of the Russian Academy of Sciences. 119333, Russian Federation, Moscow, ul. Vavilova, d. 44, кorp. 2; 2Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, pr. Sheremetevskii, d. 8
I.Yu.Torshin
Federal Research Centre "Information and Management" of the Russian Academy of Sciences. 119333, Russian Federation, Moscow, ul. Vavilova, d. 44, кorp. 2
N.K.Tetruashvili
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
L.E.Fedotova
Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, pr. Sheremetevskii, d. 8
N.P.Lapochkina
Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, pr. Sheremetevskii, d. 8
An estrogen-like activity is considered to be the main mechanism of action for Cimicifuga extract. At the same time, results of modern studies of molecular composition together with modern fundamental data indicate such critical mechanisms of action as activation of serotoninergic and GABA-ergic ways of neurotransmission, as well as anti-inflammatory and antidiabetic effects. The use of drugs based on C. racemosa extracts is perspective for accompanying replacement hormonal therapy with estrogens due to antineoplastic and osteoprotective effects of standardized C. racemosa extracts.
