Compartmentalized Biomolecular Condensates via Controlled Nucleation
Chong Wang,
Linyi Zhang,
Luoran Shang
Affiliations
Chong Wang
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences,
Fudan University, Shanghai, China.
Linyi Zhang
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences,
Fudan University, Shanghai, China.
Luoran Shang
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences,
Fudan University, Shanghai, China.
This commentary underscores the importance and implications of the study “Biomolecular condensates with complex architectures via controlled nucleation,” led by Jan C. M. van Hest and Tuomas P. J. Knowles, published in Nature Chemical Engineering. The research team developed a novel system to investigate the structure of biological condensates using quaternized amylose, carboxymethylated amylose, and single-stranded DNA. They successfully created multiphase droplets with distinct dense phases and demonstrated that droplet architecture can be controlled through temperature and salt concentration adjustments. This study offers valuable insights into the formation and function of membraneless organelles in cells and suggests promising applications for designing biomimetic materials and therapeutic strategies.
