Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Shoeb  Anwar Mohammed Khawja Ansari; Eleonora Ficiarà; Federico  Alessandro Ruffinatti; Ilaria Stura; Monica Argenziano; Ornella Abollino; Roberta Cavalli; Caterina Guiot; Federico D’Agata

doi:10.3390/ma12030465

Materials (Feb 2019)

Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Shoeb Anwar Mohammed Khawja Ansari,
Eleonora Ficiarà,
Federico Alessandro Ruffinatti,
Ilaria Stura,
Monica Argenziano,
Ornella Abollino,
Roberta Cavalli,
Caterina Guiot,
Federico D’Agata

Affiliations

Shoeb Anwar Mohammed Khawja Ansari: Department of Neuroscience, University of Turin, 10124 Turin, Italy
Eleonora Ficiarà: Department of Neuroscience, University of Turin, 10124 Turin, Italy
Federico Alessandro Ruffinatti: Department of Drug Sciences, University of Eastern Piedmont Amedeo Avogadro, 28100 Novara, Italy
Ilaria Stura: Department of Public Health and Pediatrics, University of Turin, 10124 Turin, Italy
Monica Argenziano: Department of Drug Science and Technology, University of Turin, 10124 Turin, Italy
Ornella Abollino: Department of Chemistry, University of Turin, 10124 Turin, Italy
Roberta Cavalli: Department of Drug Science and Technology, University of Turin, 10124 Turin, Italy
Caterina Guiot: Department of Neuroscience, University of Turin, 10124 Turin, Italy
Federico D’Agata: Department of Neuroscience, University of Turin, 10124 Turin, Italy

DOI: https://doi.org/10.3390/ma12030465
Journal volume & issue: Vol. 12, no. 3
p. 465

Abstract

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Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.

Published in Materials

ISSN: 1996-1944 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering; Technology: Engineering (General). Civil engineering (General); Science: Natural history (General): Microscopy; Science: Physics: Descriptive and experimental mechanics
Website: http://www.mdpi.com/journal/materials/

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