Complex pregravid preparation for women with deficiency of body weight

Abstract

Deficiency of a woman's body weight is in direct proportion to the mass of adipose tissue in the body and leads to a significant restructuring of the reproductive function endocrine mechanisms regulation. Aim. To evaluate the effectiveness of the elaborated complex pregravid preparation of women with body weight deficiency. Materials and Methods. We observed 130 women with body weight deficiency, who have visited the antenatal clinic for the purpose of planning pregnancy, 65 of them were treated with the proposed complex of therapeutic and preventive measures, 65 - traditional measures and 35 women with normal body weight. All women were determined by pituitary and ovarian hormones serum content and bone and mineral metabolism indices. The peculiarities of the proposed pregravid preparation are health food (mainly a protein-carbohydrate, daily calorie diet no less then 35 kcal/kg) and metabolic correction (prescription of combined cholecalciferol and calcium carbonate drug), which reduces in bone resorption and increases in bone density. Results. It has been noted that hormonal therapy prescription for women with deficiency of body weight, could improve ovarian hormones and prolactin indices, which influenced on menstrual cycle normalization, ovulation induction, and accordingly contributed the pregnancy. The total content of calcium, parathyroid hormone, osteocalcin and vitamin D in women treated with the proposed measures, with the inclusion of calcium carbonate and cholecalciferol, did not differ from women with normal body weight, and whereas women who received traditional therapy, they were reduced significantly. Using the elaborated system promoted a statistically significant reduction in the incidence of spontaneous abortions from 16.3% to 2.0% (P=0.015). Conclusions. Applying elaborated complex of therapeutic and preventive measures for women with low body weight, which additionally to the hormonal status normalization includes health food, combined cholecalciferol and calcium carbonate drug, has a positive effect on the functional state of bone mineral density and hormonal metabolism. It, in turn, improves the general condition of women and their reproductive health.

Keywords

• deficiency of body weight
• bone and mineral metabolism
• pregnancy planning
• ultrasound densitometry