Mitochondrial Extracellular Vesicles in CNS Disorders: New Frontiers in Understanding the Neurological Disorders of the Brain

Mary F. Nakamya; Mary F. Nakamya; Susmita Sil; Shilpa Buch; Ramin M. Hakami; Ramin M. Hakami

doi:10.3389/fmolb.2022.840364

Frontiers in Molecular Biosciences (Mar 2022)

Mitochondrial Extracellular Vesicles in CNS Disorders: New Frontiers in Understanding the Neurological Disorders of the Brain

Mary F. Nakamya,
Mary F. Nakamya,
Susmita Sil,
Shilpa Buch,
Ramin M. Hakami,
Ramin M. Hakami

Affiliations

Mary F. Nakamya: School of Systems Biology, George Mason University, Manassas, VA, United States
Mary F. Nakamya: Center for Infectious Disease Research, George Mason University, Manassas, VA, United States
Susmita Sil: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States
Shilpa Buch: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States
Ramin M. Hakami: School of Systems Biology, George Mason University, Manassas, VA, United States
Ramin M. Hakami: Center for Infectious Disease Research, George Mason University, Manassas, VA, United States

DOI: https://doi.org/10.3389/fmolb.2022.840364
Journal volume & issue: Vol. 9

Abstract

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Recent findings have highlighted potential diagnostic and prognostic values of extracellular vesicles (EVs) that contain mitochondrial derived components for neurological disorders. Furthermore, functional influences of vesicles carrying mitochondrial components have been reported. In particular, this includes indications of crosstalk with mitophagy to influence progression of various CNS disorders. In this mini-review, we discuss the current state of knowledge about this intriguing class of vesicles in neurological disorders of the CNS, and outline the lacunae and thus scope of further development in this fascinating field of study.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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Abstract

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