Mesenchymal Stem Cells in Soft Tissue Regenerative Medicine: A Comprehensive Review
Ayesha Rehman,
Aditya Nigam,
Luigi Laino,
Diana Russo,
Celestino Todisco,
Giuseppe Esposito,
Fabiano Svolacchia,
Federica Giuzio,
Vincenzo Desiderio,
Giuseppe Ferraro
Affiliations
Ayesha Rehman
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via L. Armanni 5, 80138 Naples, Italy
Aditya Nigam
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via L. Armanni 5, 80138 Naples, Italy
Luigi Laino
Multidisciplinary Department of Medicine for Surgery and Orthodontics, University of Campania “Luigi Vanvitelli”, Via L. Armanni 5, 80138 Naples, Italy
Diana Russo
Multidisciplinary Department of Medicine for Surgery and Orthodontics, University of Campania “Luigi Vanvitelli”, Via L. Armanni 5, 80138 Naples, Italy
Celestino Todisco
ASL Napoli 3 Sud., 80059 Torre del Greco, Italy
Giuseppe Esposito
ASL Napoli 3 Sud., 80059 Torre del Greco, Italy
Fabiano Svolacchia
Departments of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00118 Rome, Italy
Federica Giuzio
Department of Sciences, University of Basilicata, Via Nazario Sauro 85, 85100 Potenza, Italy
Vincenzo Desiderio
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via L. Armanni 5, 80138 Naples, Italy
Giuseppe Ferraro
Multidisciplinary Department of Medicine for Surgery and Orthodontics, University of Campania “Luigi Vanvitelli”, Via L. Armanni 5, 80138 Naples, Italy
Soft tissue regeneration holds significant promise for addressing various clinical challenges, ranging from craniofacial and oral tissue defects to blood vessels, muscle, and fibrous tissue regeneration. Mesenchymal stem cells (MSCs) have emerged as a promising tool in regenerative medicine due to their unique characteristics and potential to differentiate into multiple cell lineages. This comprehensive review explores the role of MSCs in different aspects of soft tissue regeneration, including their application in craniofacial and oral soft tissue regeneration, nerve regeneration, blood vessel regeneration, muscle regeneration, and fibrous tissue regeneration. By examining the latest research findings and clinical advancements, this article aims to provide insights into the current state of MSC-based therapies in soft tissue regenerative medicine.
