EJNMMI Physics (Jan 2023)

Dealing with dry waste disposal issues associated with 177mLu impurities: a long-term challenge for nuclear medicine departments

  • Sylviane Prevot,
  • Inna Dygaï-Cochet,
  • Jean-Marc Riedinger,
  • Jean-Marc Vrigneaud,
  • Myriam Quermonne,
  • Matthieu Gallet,
  • Alexandre Cochet

DOI
https://doi.org/10.1186/s40658-023-00524-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 7

Abstract

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Abstract Purpose A strategy for management of radioactive waste associated with 177Lu-dotatate (Lutathera®) treatments was established in our institution, based on predicted storage times of 3–5 years extrapolated from the results of a 2-year measurement study. The aim of this work was to validate this strategy by identifying contaminants and confirming disposal based on the clearance level twice-the-background was within expected time frames. Methods We conducted a prospective series of measurements of radioactive waste associated with the first 65 treatments administered. Sequential measurements of the first 45 vials used were performed on a dose calibrator to identify contaminants. Exposure rates in contact were monitored with a dose ratemeter on a 6-monthly basis for all waste stored: 46 empty vials, 19 vials partially used and 61 biohazard containers. Results Initial median activity of the first vials used was 118 MBq [4–4188 MBq]. For each vial, the decay curve of activity obtained was adjusted to a bi-exponential model. The major component, representing 99.7% of the activity, has a median half-life of 6.6 days [5.7–7.2 days] corresponding to 177Lu. The second, representing only 0.3% of the activity and having a median half-life of 152 days [104–205 days] corresponding to 177mLu, determines necessary storage times. Partially used vials can be disposed of after 5 years, other waste after 3 years. Compliance with the regulatory clearance level is achieved within expected time frames. Conclusion Although only present as traces, 177mLu associated with the direct production route results in major radioactive waste disposal issues for hospitals. Availability of radiopharmaceuticals without impurities appears to be crucial for an expanding use of targeted radionuclide therapy.

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