Nature Communications (Dec 2016)

Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53

  • Tengfei Chao,
  • Xiang Zhou,
  • Bo Cao,
  • Peng Liao,
  • Hongbing Liu,
  • Yun Chen,
  • Hee-Won Park,
  • Shelya X. Zeng,
  • Hua Lu

DOI
https://doi.org/10.1038/ncomms13755
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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p53 is an oncosuppressor regulating several genes at the transcriptional level. Here, the authors identify a negative feedback loop between PHLDB3 and p53; PHLDB3 is a transcriptional target of p53 which facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis.