Nature Communications (Dec 2016)
Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
Abstract
p53 is an oncosuppressor regulating several genes at the transcriptional level. Here, the authors identify a negative feedback loop between PHLDB3 and p53; PHLDB3 is a transcriptional target of p53 which facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis.