A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

Yifei Zhou; Xueqing Wang; Mengjiao Song; Zhidong He; Guizhong Cui; Guangdun Peng; Christoph Dieterich; Adam Antebi; Naihe Jing; Yidong Shen

doi:10.1038/s41467-019-12821-2

Nature Communications (Oct 2019)

A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

Yifei Zhou,
Xueqing Wang,
Mengjiao Song,
Zhidong He,
Guizhong Cui,
Guangdun Peng,
Christoph Dieterich,
Adam Antebi,
Naihe Jing,
Yidong Shen

Affiliations

Yifei Zhou: State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xueqing Wang: State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Mengjiao Song: State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Zhidong He: State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Guizhong Cui: State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Guangdun Peng: CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Christoph Dieterich: Klaus Tschira Institute for Integrative Computational Cardiology and Department of Internal Medicine III, University Hospital Heidelberg
Adam Antebi: Max Planck Institute for Biology of Ageing
Naihe Jing: State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Yidong Shen: State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-12821-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Decreased autophagy is a hallmark of ageing, but its inter-tissue regulation is poorly understood. Here, Zhou et al. identify mir-83 in C. elegans, which is transported across tissues and suppresses autophagy, contributing to age-related decline.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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