Communications Biology (Apr 2022)
Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity
- Theresa V. Rohm,
- Lena Keller,
- Angela J. T. Bosch,
- Shefaa AlAsfoor,
- Zora Baumann,
- Amandine Thomas,
- Sophia J. Wiedemann,
- Laura Steiger,
- Elise Dalmas,
- Josua Wehner,
- Leila Rachid,
- Catherine Mooser,
- Bahtiyar Yilmaz,
- Nerea Fernandez Trigo,
- Annaise J. Jauch,
- Stephan Wueest,
- Daniel Konrad,
- Sandrine Henri,
- Jan H. Niess,
- Petr Hruz,
- Stephanie C. Ganal-Vonarburg,
- Julien Roux,
- Daniel T. Meier,
- Claudia Cavelti-Weder
Affiliations
- Theresa V. Rohm
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Lena Keller
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Angela J. T. Bosch
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Shefaa AlAsfoor
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Zora Baumann
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Amandine Thomas
- Biozentrum, University of Basel
- Sophia J. Wiedemann
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Laura Steiger
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Elise Dalmas
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Josua Wehner
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Leila Rachid
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Catherine Mooser
- Department of Visceral Surgery und Medicine, Bern University Hospital, University of Bern
- Bahtiyar Yilmaz
- Department of Visceral Surgery und Medicine, Bern University Hospital, University of Bern
- Nerea Fernandez Trigo
- Department of Visceral Surgery und Medicine, Bern University Hospital, University of Bern
- Annaise J. Jauch
- Department of Biomedicine (DBM), University of Basel, University Hospital Basel
- Stephan Wueest
- Division of Pediatric Endocrinology and Diabetology, and Children’s Research Center, University Children’s Hospital, University of Zurich
- Daniel Konrad
- Division of Pediatric Endocrinology and Diabetology, and Children’s Research Center, University Children’s Hospital, University of Zurich
- Sandrine Henri
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS
- Jan H. Niess
- Department of Biomedicine (DBM), University of Basel, University Hospital Basel
- Petr Hruz
- Department of Biomedicine (DBM), University of Basel, University Hospital Basel
- Stephanie C. Ganal-Vonarburg
- Department of Visceral Surgery und Medicine, Bern University Hospital, University of Bern
- Julien Roux
- Department of Biomedicine (DBM), University of Basel, University Hospital Basel
- Daniel T. Meier
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- Claudia Cavelti-Weder
- Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
- DOI
- https://doi.org/10.1038/s42003-022-03305-z
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the colon improves glucose metabolism.
