Nature Communications (May 2021)
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
- Nathalie M. Schmidt,
- Peter A. C. Wing,
- Mariana O. Diniz,
- Laura J. Pallett,
- Leo Swadling,
- James M. Harris,
- Alice R. Burton,
- Anna Jeffery-Smith,
- Nekisa Zakeri,
- Oliver E. Amin,
- Stephanie Kucykowicz,
- Mirjam H. Heemskerk,
- Brian Davidson,
- Tim Meyer,
- Joe Grove,
- Hans J. Stauss,
- Ines Pineda-Torra,
- Clare Jolly,
- Elizabeth C. Jury,
- Jane A. McKeating,
- Mala K. Maini
Affiliations
- Nathalie M. Schmidt
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Peter A. C. Wing
- Nuffield Department of Medicine, Oxford University
- Mariana O. Diniz
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Laura J. Pallett
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Leo Swadling
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- James M. Harris
- Nuffield Department of Medicine, Oxford University
- Alice R. Burton
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Anna Jeffery-Smith
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Nekisa Zakeri
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Oliver E. Amin
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Stephanie Kucykowicz
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Mirjam H. Heemskerk
- Department of Hematology, Leiden University Medical Center
- Brian Davidson
- Division of Surgery, University College London
- Tim Meyer
- Royal Free London NHS Foundation Trust
- Joe Grove
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Hans J. Stauss
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Ines Pineda-Torra
- Division of Medicine, University College London
- Clare Jolly
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- Elizabeth C. Jury
- Division of Medicine, University College London
- Jane A. McKeating
- Nuffield Department of Medicine, Oxford University
- Mala K. Maini
- Division of Infection & Immunity, Institute of Immunity & Transplantation, University College London
- DOI
- https://doi.org/10.1038/s41467-021-22967-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses from human liver and hepatocellular carcinoma.
