Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat
Balázs Varga,
Dániel Priksz,
Nóra Lampé,
Mariann Bombicz,
Andrea Kurucz,
Adrienn Mónika Szabó,
Anikó Pósa,
Renáta Szabó,
Ádám Kemény-Beke,
Judit Remenyik,
Rudolf Gesztelyi,
Béla Juhász
Affiliations
Balázs Varga
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Dániel Priksz
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Nóra Lampé
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Mariann Bombicz
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Andrea Kurucz
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Adrienn Mónika Szabó
Department of Internal Medicine, Building C, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Anikó Pósa
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H6726, Hungary
Renáta Szabó
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H6726, Hungary
Ádám Kemény-Beke
Department of Ophtalmology, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Judit Remenyik
Institute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen H4032, Hungary
Rudolf Gesztelyi
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Béla Juhász
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary
Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats. Our results prove that the SCSE has a retinoprotective effect in diabetic rats: according to ERG measurements, SCSE treatment mitigated the retinal function-damaging effect of diabetes, and proved to be protective in the diabetic eye against ischemia-reperfusion injuries of the retina. Outcomes suggest that the protective effects of SCSE may occur through several pathways, including HO-1 dependent mechanisms. The observation that SCSE treatment decreases blood glucose is also novel. These findings offer the possibility for development of novel therapeutic strategies utilizing this emerging functional food, in particular in the prevention of conditions resulting from high blood glucose or I/R injury, such as deterioration of retinal microcirculation.
