Associates of poor physical and mental health-related quality of life in beta thalassemia-major/intermedia

Abstract

<ul><li><strong><span style="font-size: 8pt;">BACKGROUND</span></strong><strong><span style="font-size: 8pt;">:</span></strong> Using two logistic regression models, we determined the associates of poor physical and mental health related quality of life (HRQoL) among beta thalassemia patients.</li><li><strong><span style="font-size: 8pt;">METHODS</span></strong><strong><span style="font-size: 8pt;">:</span></strong> In this cross-sectional study which was conducted during 2006 and 2007 in outpatient adult thalassemia clinic, Blood Transfusion Organization, Tehran, Iran, Short Form 36 (SF-36) was used for measuring HRQoL in 179 patients with beta thalassemia (major/intermedia). <span>We determined scores higher than third quartiles of obtained PCS and MCS scores as the cutoff points of good HRQoL. Poor HRQoL was defined scores lower than first quartiles of obtained PCS and MCS scores.</span> Two distinct logistic regression models were used to derive associated variables including demographic, clinical, and psychological factors.</li><li><strong><span style="font-size: 8pt;">RESULTS</span></strong><strong><span style="font-size: 8pt;">:</span></strong> The regression models suggested that poor physical HRQoL was positively associated with somatic comorbidities (OR = 1.472, CI = 1.021-2.197, p = 0.048) and depression score (OR = 8.568, CI = 2.325-31.573, p = 0.001). The variables that were associated with poor mental HRQoL were anxiety score (OR = 9.409, CI = 1.022-89.194, p = 0.049) and depression score (OR = 20.813, CI = 4.320-100.266, p &lt; 0.001).</li><li><strong><span style="font-size: 8pt;">CONCLUSIONS</span></strong><strong><span style="font-size: 8pt;">:</span></strong> Depression is associated with both poor physical and mental HRQoL among patients with major/intermedia beta thalassemia, however somatic comorbidities and anxiety are associated with poor physical and mental HRQoL, respectively.</li><li><strong><span style="font-size: 8pt;">KEYWORDS</span></strong><strong><span style="font-size: 8pt;">:</span></strong> Thalassemia, Health Related Quality of Life, Anxiety, Depression, Somatic Comorbidities.</li></ul><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml><![endif]--> <!--[endif]-->

Keywords

• halassemia, Health Related Quality of Life, Anxiety, Depression, Somatic Comorbidities.