“Evaluation of wound healing and bone regeneration using autologous platelet-rich plasma and platelet-rich fibrin postextractions”: A comparative study

Abstract

Introduction: It has already been established in the past that platelets play a major role in wound healing. Platelet- rich plasma (PRP) and Platelet- rich fibrin (PRF) are autologous concentrates of platelets in a relatively small volume of plasma and they enable delivery of growth factors in increased amounts to surgical sites to promote wound healing. Aims and Objectives: This study focuses on comparing the two platelet concentrates – platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) as graft materials in extraction sockets and their efficacy in wound healing and bone regeneration. Materials and Methods: Sixty patients requiring extraction of unilateral third molars were considered. Computer-generated random allocation of subjects was done. Group A: PRP was used as the graft material in the third molar extraction socket Group B: PRF was used as the graft material in the third molar extraction socket Group C: No material was used as graft in the third molar extraction socket. Soft tissue healing and bone healing were assessed in the postoperative follow up visits. Results: We observed that Group B showed significantly improved soft tissue healing and a faster bone healing as compared to Group A. Both Group A and Group B showed significantly better healing in terms of soft tissue and bone as compared to Group C. Conclusion: PRF shows better results in terms of soft tissue and bone healing as compared to PRP. The method of procuring PRF is easy as compared to that of procuring PRP.

Keywords

• Autologous graft materials
• bone healing
• platelet-rich fibrin
• platelet-rich plasma
• soft tissue healing