Mechanism of ERK/CREB pathway in pain and analgesia

Weizhe Zhen; Weizhe Zhen; Hongjun Zhen; Yuye Wang; Yuye Wang; Leian Chen; Leian Chen; Xiaoqian Niu; Xiaoqian Niu; Bin Zhang; Bin Zhang; Ziyuan Yang; Ziyuan Yang; Dantao Peng; Dantao Peng

doi:10.3389/fnmol.2023.1156674

Frontiers in Molecular Neuroscience (Mar 2023)

Mechanism of ERK/CREB pathway in pain and analgesia

Weizhe Zhen,
Weizhe Zhen,
Hongjun Zhen,
Yuye Wang,
Yuye Wang,
Leian Chen,
Leian Chen,
Xiaoqian Niu,
Xiaoqian Niu,
Bin Zhang,
Bin Zhang,
Ziyuan Yang,
Ziyuan Yang,
Dantao Peng,
Dantao Peng

Affiliations

Weizhe Zhen: Graduate School, Beijing University of Chinese Medicine, Beijing, China
Weizhe Zhen: Department of Neurology, China-Japan Friendship Hospital, Beijing, China
Hongjun Zhen: Department of Orthopaedics, Handan Chinese Medicine Hospital, Handan, Hebei Province, China
Yuye Wang: Department of Neurology, China-Japan Friendship Hospital, Beijing, China
Yuye Wang: Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Leian Chen: Department of Neurology, China-Japan Friendship Hospital, Beijing, China
Leian Chen: Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Xiaoqian Niu: Department of Neurology, China-Japan Friendship Hospital, Beijing, China
Xiaoqian Niu: Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China
Bin Zhang: Department of Neurology, China-Japan Friendship Hospital, Beijing, China
Bin Zhang: Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Ziyuan Yang: Department of Neurology, China-Japan Friendship Hospital, Beijing, China
Ziyuan Yang: Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China
Dantao Peng: Graduate School, Beijing University of Chinese Medicine, Beijing, China
Dantao Peng: Department of Neurology, China-Japan Friendship Hospital, Beijing, China

DOI: https://doi.org/10.3389/fnmol.2023.1156674
Journal volume & issue: Vol. 16

Abstract

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Research has long centered on the pathophysiology of pain. The Transient Receiver Potential (TRP) protein family is well known for its function in the pathophysiology of pain, and extensive study has been done in this area. One of the significant mechanisms of pain etiology and analgesia that lacks a systematic synthesis and review is the ERK/CREB (Extracellular Signal-Regulated Kinase/CAMP Response Element Binding Protein) pathway. The ERK/CREB pathway-targeting analgesics may also cause a variety of adverse effects that call for specialized medical care. In this review, we systematically compiled the mechanism of the ERK/CREB pathway in the process of pain and analgesia, as well as the potential adverse effects on the nervous system brought on by the inhibition of the ERK/CREB pathway in analgesic drugs, and we suggested the corresponding solutions.

Published in Frontiers in Molecular Neuroscience

ISSN: 1662-5099 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/molecular-neuroscience

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