Nature Communications (Oct 2017)
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas
- Huan Wang,
- Aaron Bender,
- Peng Wang,
- Esra Karakose,
- William B. Inabnet,
- Steven K. Libutti,
- Andrew Arnold,
- Luca Lambertini,
- Micheal Stang,
- Herbert Chen,
- Yumi Kasai,
- Milind Mahajan,
- Yayoi Kinoshita,
- Gustavo Fernandez-Ranvier,
- Thomas C. Becker,
- Karen K. Takane,
- Laura A. Walker,
- Shira Saul,
- Rong Chen,
- Donald K. Scott,
- Jorge Ferrer,
- Yevgeniy Antipin,
- Michael Donovan,
- Andrew V. Uzilov,
- Boris Reva,
- Eric E. Schadt,
- Bojan Losic,
- Carmen Argmann,
- Andrew F. Stewart
Affiliations
- Huan Wang
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Aaron Bender
- The Graduate School, The Icahn School of Medicine at Mount Sinai
- Peng Wang
- The Diabetes Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai
- Esra Karakose
- The Diabetes Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai
- William B. Inabnet
- The Department of Surgery, The Icahn School of Medicine at Mount Sinai
- Steven K. Libutti
- The Cancer Institute of New Jersey, Rutgers University
- Andrew Arnold
- Center for Molecular Medicine, University of Connecticut School of Medicine
- Luca Lambertini
- The Departments of Environmental Medicine and Public Health and Obstetrics, Gynecology, and Reproductive Sciences, The Icahn School of Medicine at Mount Sinai
- Micheal Stang
- The Department of Surgery, Duke University School of Medicine
- Herbert Chen
- The Department of Surgery, University of Alabama at Birmingham
- Yumi Kasai
- The New York Genome Center
- Milind Mahajan
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Yayoi Kinoshita
- The Department of Pathology, The Icahn School of Medicine at Mount Sinai
- Gustavo Fernandez-Ranvier
- The Department of Surgery, The Icahn School of Medicine at Mount Sinai
- Thomas C. Becker
- The Sarah W. Stedman Center for Nutrition and Metabolism, Duke University School of Medicine
- Karen K. Takane
- The Diabetes Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai
- Laura A. Walker
- The Diabetes Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai
- Shira Saul
- The Diabetes Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai
- Rong Chen
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Donald K. Scott
- The Diabetes Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai
- Jorge Ferrer
- The Department of Genetics in Medicine, Imperial College
- Yevgeniy Antipin
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Michael Donovan
- The Department of Pathology, The Icahn School of Medicine at Mount Sinai
- Andrew V. Uzilov
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Boris Reva
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Eric E. Schadt
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Bojan Losic
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Carmen Argmann
- The Department of Genetics and Genomic Sciences and The Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai
- Andrew F. Stewart
- The Diabetes Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-017-00992-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Diabetes results in part from a deficiency of functional pancreatic beta cells. Here, the authors study the genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for therapeutic beta cell regeneration, highlighting epigenetic genes and pathways.
