Nature Communications (Sep 2019)

Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells

  • Nilda Vanesa Ayala-Nunez,
  • Gautier Follain,
  • François Delalande,
  • Aurélie Hirschler,
  • Emma Partiot,
  • Gillian L. Hale,
  • Brigid C. Bollweg,
  • Judith Roels,
  • Maxime Chazal,
  • Florian Bakoa,
  • Margot Carocci,
  • Sandrine Bourdoulous,
  • Orestis Faklaris,
  • Sherif R. Zaki,
  • Anita Eckly,
  • Béatrice Uring-Lambert,
  • Frédéric Doussau,
  • Sarah Cianferani,
  • Christine Carapito,
  • Frank M. J. Jacobs,
  • Nolwenn Jouvenet,
  • Jacky G. Goetz,
  • Raphael Gaudin

DOI
https://doi.org/10.1038/s41467-019-12408-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus.