Longitudinal Measurement of Histidine-Rich Glycoprotein Levels in Bronchopulmonary Dysplasia: A Pilot Study
Daisaku Morimoto,
Yosuke Washio,
Kei Tamai,
Takeshi Sato,
Tomoka Okamura,
Hirokazu Watanabe,
Yu Fukushima,
Junko Yoshimoto,
Misao Kageyama,
Kenji Baba,
Hirokazu Tsukahara
Affiliations
Daisaku Morimoto
Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho Kita-ku, Okayama 700-8558, Japan
Yosuke Washio
Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho Kita-ku, Okayama 700-8558, Japan
Kei Tamai
Division of Neonatology, Okayama Medical Center, National Hospital Organization, Okayama, 1711-1 Tamasu Kita-ku, Okayama 701-1192, Japan
Takeshi Sato
Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho Kita-ku, Okayama 700-8558, Japan
Tomoka Okamura
Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho Kita-ku, Okayama 700-8558, Japan
Hirokazu Watanabe
Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho Kita-ku, Okayama 700-8558, Japan
Yu Fukushima
Division of Neonatology, Okayama Medical Center, National Hospital Organization, Okayama, 1711-1 Tamasu Kita-ku, Okayama 701-1192, Japan
Junko Yoshimoto
Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho Kita-ku, Okayama 700-8558, Japan
Misao Kageyama
Division of Neonatology, Okayama Medical Center, National Hospital Organization, Okayama, 1711-1 Tamasu Kita-ku, Okayama 701-1192, Japan
Kenji Baba
Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho Kita-ku, Okayama 700-8558, Japan
Hirokazu Tsukahara
Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho Kita-ku, Okayama 700-8558, Japan
Histidine-rich glycoprotein (HRG) has been reported to inhibit signaling leading to the release of high mobility group box 1 protein, a damage-associated molecular pattern. The present study aimed to determine the longitudinal change in HRG levels in extremely preterm infants and assess whether complications such as bronchopulmonary dysplasia (BPD) were associated with differences in HRG levels. In this multicenter, prospective, observational study, we measured serum HRG levels every 2 weeks from birth to 8 weeks of age. Serum HRG was measured using an enzyme-linked immunosorbent assay. We included 19 extremely preterm infants in the study and 74 samples were analyzed. The median gestational age was 26.0 weeks, and the median birth weight was 858 g. Serum HRG levels showed a significant upward trend after birth (p < 0.001); median HRG concentrations at birth and at 2, 4, 6, and 8 weeks of age were 1.07, 1.11, 2.86, 6.05, and 7.49 µg/mL, respectively. Onset of BPD was not associated with differences in serum HRG levels. Further, the serum HRG levels increased significantly after birth in extremely preterm infants.
