Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus

Abstract

Yasuyuki Kawai, Ryoko Sato-Ishida, Atsushi Motoyama, Kouji KajinamiDepartment of Cardiology, Kanazawa Medical University, Uchinada, JapanAbstract: Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known as statins, have revolutionized the treatment of hypercholesterolemia and coronary artery disease prevention. However, there are considerable issues regarding statin safety and further development of residual risk control, particularly for diabetic and metabolic syndrome patients. Pitavastatin is a potent statin with low-density lipoprotein (LDL) cholesterol-lowering effects comparable to those of atorvastatin or rosuvastatin. Pitavastatin has a high-density lipoprotein (HDL) cholesterol raising effect, may improve insulin resistance, and has little influence on glucose metabolism. Considering these factors along with its unique pharmacokinetic properties, which suggest minimal drug–drug interaction, pitavastatin could provide an alternative treatment choice, especially in patients with glucose intolerance or diabetes mellitus. Many clinical trials are now underway to test the clinical efficacy of pitavastatin in various settings and are expected to provide further information.Keywords: HMG-CoA reductase inhibitor, pitavastatin, efficacy, safety, diabetes mellitus