Association of anemia with hyperadiponectinemia in oldest–old Japanese women who resided at home alone without wheelchair use

Abstract

Abstract The association of anemia with hyperadiponectinemia (HAN) (≥ 20 μg/mL) was studied in 95 Japanese women aged 65–74 (young–old), 175 women aged 75–84 (old–old), and 51 women aged over 85 (oldest–old) who resided at home alone without wheelchair use. The prevalence of anemia was 21.5% overall and increased with aging stepwise (9.5, 22.9, and 39.2% in young–olds, old–olds, and oldest–olds, respectively, p < 0.001). Most of the anemia was normocytic and only one woman had hemoglobin < 10 g/dL. Old–olds with anemia had low serum iron, albumin, and cholesterol and a higher prevalence of renal insufficiency (30.0 versus 5.2%, p < 0.001). In contrast, these variables did not differ between anemic and non-anemic young–olds. oldest–olds with anemia had low serum iron and higher adiponectin concentrations (22.8 ± 9.8 vs. 16.0 ± 6.7 μg/mL, p = 0.005) and prevalence of HAN (60.0 vs. 19.4%, p = 0.006) and renal insufficiency (50.0 vs. 0%, p < 0.001). However, inflammatory markers did not differ between anemic and non-anemic oldest–olds. The prevalence of anemia was higher in oldest–olds with versus without HAN (66.7 vs. 24.2%, p = 0.006). In multivariable logistic regression analysis, anemia was associated with HAN (OR: 15.7, 95% CI 1.2–207, p = 0.03) in oldest–olds and with renal insufficiency (OR: 7.1, 95% CI 2.4–21.0, p < 0.001) in old–olds. In conclusion, the association of anemia with HAN was evident in oldest–old Japanese women, suggesting the anti-inflammatory properties of circulating adiponectin.

Keywords

• Adiponectin
• Hemoglobin
• Anemia
• Eryptosis
• Oldest–olds