Radiology Case Reports (Nov 2023)
Spontaneous regression of small cell lung cancer associated with Lambert-Eaton Myasthenic Syndrome: Case report
- Michimi Otani, MD,
- Miki Nishimori, MD, PhD,
- Hitomi Iwasa, MD, PhD,
- Mamiko Iwamura, MD,
- Takayasu Izumi, MD,
- Kosuke Nakaji, MD,
- Noriko Nitta, MD,
- Kana Miyatake, MD,
- Rika Yoshimatsu, MD, PhD,
- Tomoaki Yamanishi, MD,
- Tomohiro Matsumoto, MD, PhD,
- Yasushi Osaki, MD, PhD,
- Noriko Wada, MD,
- Makoto Toi, MD, PhD,
- Marino Yamamoto, MD, PhD,
- Yu Nakatani, MD,
- Tetsuya Kubota, MD, PhD,
- Takuji Yamagami, MD, PhD
Affiliations
- Michimi Otani, MD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Miki Nishimori, MD, PhD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan; Corresponding author.
- Hitomi Iwasa, MD, PhD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Mamiko Iwamura, MD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Takayasu Izumi, MD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Kosuke Nakaji, MD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Noriko Nitta, MD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Kana Miyatake, MD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Rika Yoshimatsu, MD, PhD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Tomoaki Yamanishi, MD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Tomohiro Matsumoto, MD, PhD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Yasushi Osaki, MD, PhD
- Department of Neurology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan
- Noriko Wada, MD
- Department of Diagnostic Pathology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan
- Makoto Toi, MD, PhD
- Department of Diagnostic Pathology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan
- Marino Yamamoto, MD, PhD
- Department of Thoracic Surgery, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan
- Yu Nakatani, MD
- Department of Respiratory Medicine and Allergology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan
- Tetsuya Kubota, MD, PhD
- Department of Respiratory Medicine and Allergology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan
- Takuji Yamagami, MD, PhD
- Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan
- Journal volume & issue
-
Vol. 18,
no. 11
pp. 4036 – 4041
Abstract
Spontaneous regression (SR) of cancer is very rare, especially of small cell lung cancer (SCLC). Recently, an association of paraneoplastic neurological syndrome (PNS) has been reported as a cause of SR of cancer, and onconeural antibodies are a possible factor in the SR of cancer associated with PNS. We herein report the first case of SR of SCLC combined with anti-P/Q-type of voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS), a subtype of PNS. This case report suggests that SCLC may be spontaneously reduced by an autoimmune response induced by VGCC antibodies associated with LEMS. Our finding may help elucidate the mechanisms that inhibit tumor growth and cause the regression of tumors.
