eLife (Dec 2020)
Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia
- Michaela Gregorova,
- Daniel Morse,
- Tarcisio Brignoli,
- Joseph Steventon,
- Fergus Hamilton,
- Mahableshwar Albur,
- David Arnold,
- Matthew Thomas,
- Alice Halliday,
- Holly Baum,
- Christopher Rice,
- Matthew B Avison,
- Andrew D Davidson,
- Marianna Santopaolo,
- Elizabeth Oliver,
- Anu Goenka,
- Adam Finn,
- Linda Wooldridge,
- Borko Amulic,
- Rosemary J Boyton,
- Daniel M Altmann,
- David K Butler,
- Claire McMurray,
- Joanna Stockton,
- Sam Nicholls,
- Charles Cooper,
- Nicholas Loman,
- Michael J Cox,
- Laura Rivino,
- Ruth C Massey
Affiliations
- Michaela Gregorova
- ORCiD
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Daniel Morse
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Tarcisio Brignoli
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Joseph Steventon
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Fergus Hamilton
- North Bristol NHS Trust, Bristol, United Kingdom
- Mahableshwar Albur
- ORCiD
- North Bristol NHS Trust, Bristol, United Kingdom
- David Arnold
- ORCiD
- North Bristol NHS Trust, Bristol, United Kingdom
- Matthew Thomas
- North Bristol NHS Trust, Bristol, United Kingdom
- Alice Halliday
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Holly Baum
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Christopher Rice
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Matthew B Avison
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Andrew D Davidson
- ORCiD
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Marianna Santopaolo
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Elizabeth Oliver
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Anu Goenka
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Adam Finn
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Linda Wooldridge
- Bristol Veterinary School in the Faculty of Health Sciences, Bristol, United Kingdom
- Borko Amulic
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Rosemary J Boyton
- Department of Infectious Disease, Imperial College London, London, United Kingdom; Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom
- Daniel M Altmann
- Department of Infectious Disease, Imperial College London, London, United Kingdom
- David K Butler
- Department of Infectious Disease, Imperial College London, London, United Kingdom
- Claire McMurray
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
- Joanna Stockton
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
- Sam Nicholls
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
- Charles Cooper
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
- Nicholas Loman
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom
- Michael J Cox
- Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom
- Laura Rivino
- ORCiD
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- Ruth C Massey
- ORCiD
- School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
- DOI
- https://doi.org/10.7554/eLife.63430
- Journal volume & issue
-
Vol. 9
Abstract
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.
Keywords
