FEBS Open Bio
(Jan 2020)
Methylation of drug resistance‐related genes in chemotherapy‐sensitive Epstein–Barr virus‐associated gastric cancer
Hirofumi Ohmura,
Mamoru Ito,
Keita Uchino,
Chihiro Okada,
Shigeki Tanishima,
Yuichi Yamada,
Seiya Momosaki,
Masato Komoda,
Miyuki Kuwayama,
Kyoko Yamaguchi,
Yuta Okumura,
Michitaka Nakano,
Kenji Tsuchihashi,
Taichi Isobe,
Hiroshi Ariyama,
Hitoshi Kusaba,
Yoshinao Oda,
Koichi Akashi,
Eishi Baba
Affiliations
Hirofumi Ohmura
Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan
Mamoru Ito
Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan
Keita Uchino
Department of Clinical Oncology NTT Medical Center Tokyo Japan
Chihiro Okada
Engineering Section Biomedical Informatics Development Department Kansai Division Mitsubishi Space Software Hyogo Japan
Shigeki Tanishima
Engineering Section Biomedical Informatics Development Department Kansai Division Mitsubishi Space Software Hyogo Japan
Yuichi Yamada
Department of Anatomic Pathology Graduate School of Medical Sciences Kyushu University Fukuoka Japan
Seiya Momosaki
Department of Pathology National Hospital Organization Kyushu Medical Center Fukuoka Japan
Masato Komoda
Department of Gastrointestinal and Medical Oncology National Hospital Organization Kyushu Cancer Center Fukuoka Japan
Miyuki Kuwayama
Department of Internal Medicine Munakata Medical Association Hospital Fukuoka Japan
Kyoko Yamaguchi
Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan
Yuta Okumura
Department of Internal Medicine Kyushu University Beppu Hospital Oita Japan
Michitaka Nakano
Department of Gastrointestinal and Medical Oncology National Hospital Organization Kyushu Cancer Center Fukuoka Japan
Kenji Tsuchihashi
Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan
Taichi Isobe
Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan
Hiroshi Ariyama
Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan
Hitoshi Kusaba
Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan
Yoshinao Oda
Department of Anatomic Pathology Graduate School of Medical Sciences Kyushu University Fukuoka Japan
Koichi Akashi
Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan
Eishi Baba
Department of Oncology and Social Medicine Kyushu University Graduate School of Medical Sciences Fukuoka Japan
DOI
https://doi.org/10.1002/2211-5463.12765
Journal volume & issue
Vol. 10,
no. 1
Abstract
Read online
Epstein–Barr virus (EBV)‐associated gastric cancer (GC) is associated with a high degree of DNA methylation. However, the association between chemotherapy susceptibility and tumor DNA methylation in advanced diseases remains unclear. The comprehensive DNA methylation status of GC cells obtained from an advanced EBV‐associated GC (EBVGC) case, in which complete response to S‐1 plus cisplatin chemotherapy was achieved, was analyzed using a DNA methylation microarray. We compared DNA methylation of GC cells with public data and identified genes with higher methylation in EBVGC cell lines than in normal gastric cells, and genes in which methylation was increased by EBV. Of these genes, ABCG2, AHNAK2, BCL2, FZD1, and TP73 are associated with published evidence for resistance to 5‐fluorouracil and cisplatin. Silencing of these genes may be associated with hypersensitivity to chemotherapy.
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