Nature Communications (Jun 2021)
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes
- Jiwen Li,
- Lin Pan,
- William G. Pembroke,
- Jessica E. Rexach,
- Marlesa I. Godoy,
- Michael C. Condro,
- Alvaro G. Alvarado,
- Mineli Harteni,
- Yen-Wei Chen,
- Linsey Stiles,
- Angela Y. Chen,
- Ina B. Wanner,
- Xia Yang,
- Steven A. Goldman,
- Daniel H. Geschwind,
- Harley I. Kornblum,
- Ye Zhang
Affiliations
- Jiwen Li
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- Lin Pan
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- William G. Pembroke
- Department of Neurology, David Geffen School of Medicine at the University of California
- Jessica E. Rexach
- Department of Neurology, David Geffen School of Medicine at the University of California
- Marlesa I. Godoy
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- Michael C. Condro
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- Alvaro G. Alvarado
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- Mineli Harteni
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- Yen-Wei Chen
- Department of Integrative Biology and Physiology, University of California
- Linsey Stiles
- Department of Endocrinology, David Geffen School of Medicine at the University of California
- Angela Y. Chen
- Department of Obstetrics and Gynecology, University of California
- Ina B. Wanner
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- Xia Yang
- Department of Integrative Biology and Physiology, University of California
- Steven A. Goldman
- Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center
- Daniel H. Geschwind
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- Harley I. Kornblum
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- Ye Zhang
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California
- DOI
- https://doi.org/10.1038/s41467-021-24232-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hypoxic and inflammatory conditions.
