Nature Communications (Apr 2022)
Photoinduced ynamide structural reshuffling and functionalization
Abstract
Although ynamides have emerged as a versatile class of compounds for organic synthesis, the radical chemistry of ynamides usually proceeds with the expected connectivity largely intact. Here the authors show a methodology by which the C(sp)–N bond undergoes scission, alkyne migration and functionalization under blue LED light in the absence of metals or additives.